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Advances on immune-related adverse events associated with immune checkpoint inhibitors
Yong Fan, Yan Geng, Lin Shen, Zhuoli Zhang
Frontiers of Medicine 2021, Volume 15, Issue 1, Pages 33-42 doi: 10.1007/s11684-019-0735-3
Keywords: cancer immunotherapy immune checkpoint inhibitors immune-related adverse events review
FGF13 suppresses acute myeloid leukemia by regulating bone marrow niches
Frontiers of Medicine 2022, Volume 16, Issue 6, Pages 896-908 doi: 10.1007/s11684-022-0944-z
Keywords: acute myeloid leukemia FGF13 prognosis immune-related genes bone marrow niches
Multi-target combinatory strategy to overcome tumor immune escape
Frontiers of Medicine 2022, Volume 16, Issue 2, Pages 208-215 doi: 10.1007/s11684-022-0922-5
Keywords: immune checkpoints multi-target immune escape immune-related adverse events combination therapy
Expression profiles of genes and enzymes related to ascorbic acid metabolism in fruits of
Yingying CHEN,Zhihui ZHAO,Jin ZHAO,Mengjun LIU
Frontiers of Agricultural Science and Engineering 2016, Volume 3, Issue 2, Pages 131-136 doi: 10.15302/J-FASE-2016096
Keywords: Chinese jujube ascorbic acid metabolism gene enzyme
Changes in lncRNAs and related genes in β-thalassemia minor and β-thalassemia major
Jing Ma,Fei Liu,Xin Du,Duan Ma,Likuan Xiong
Frontiers of Medicine 2017, Volume 11, Issue 1, Pages 74-86 doi: 10.1007/s11684-017-0503-1
β-thalassemia is caused by β-globin gene mutations. However, heterogeneous phenotypes were found in individuals with same genotype, and still undescribed mechanism underlies such variation. We collected blood samples from 30 β-thalassemia major, 30 β-thalassemia minor patients, and 30 matched normal controls. Human lncRNA Array v2.0 (8 × 60 K, Arraystar) was used to detect changes in long non-coding RNAs (lncRNAs) and mRNAs in three samples each from β-thalassemia major, β-thalassemia minor, and control groups. Compared with normal controls, 1424 and 2045 lncRNAs were up- and downregulated, respectively, in β-thalassemia major patients, whereas 623 and 349 lncRNAs were up- and downregulated, respectively, in β-thalassemia minor patients. Compared with β-thalassemia minor group, 1367 and 2356 lncRNAs were up- and downregulated, respectively, in β-thalassemia major group. We selected five lncRNAs that displayed altered expressions (DQ583499, X-inactive specific transcript (Xist), lincRNA-TPM1, MRFS16P, and lincRNA-RUNX2-2) and confirmed their expression levels in all samples using real-time polymerase chain reaction. Based on coding-non-coding gene co-expression network and gene ontology biological process analyses, several signaling pathways were associated with three common organ systems exhibiting β-thalassemia phenotypes: hematologic, skeletal, and hepatic systems. This study implicates that abnormal expression levels of lncRNAs and mRNA in β-thalassemia cases may be correlated with its various clinical phenotypes.
Keywords: β-thalassemia long non-coding RNA mRNA phenotypic heterogeneity pathway
Frontiers of Medicine 2022, Volume 16, Issue 6, Pages 883-895 doi: 10.1007/s11684-022-0919-0
Keywords: osteosarcoma autophagy metastasis drug resistance Beclin1 LC3B
Metagenomic analysis on resistance genes in water and microplastics from a mariculture system
Frontiers of Environmental Science & Engineering 2022, Volume 16, Issue 1, Pages 4-4 doi: 10.1007/s11783-021-1438-y
Keywords: Antibiotic resistance genes Metal resistance genes Metagenomic analysis Microplastics Mariculture
Natural killer cells in liver diseases
Meijuan Zheng, Haoyu Sun, Zhigang Tian
Frontiers of Medicine 2018, Volume 12, Issue 3, Pages 269-279 doi: 10.1007/s11684-018-0621-4
Keywords: natural killer cell phenotype immune activation immune tolerance liver diseases
Tangchun Wu
Frontiers of Medicine 2020, Volume 14, Issue 6, Pages 816-819 doi: 10.1007/s11684-020-0823-4
Heterogeneity of the tumor immune microenvironment and clinical interventions
Frontiers of Medicine 2023, Volume 17, Issue 4, Pages 617-648 doi: 10.1007/s11684-023-1015-9
Keywords: Heterogeneity tumor immune
Molecular classification and precision therapy of cancer: immune checkpoint inhibitors
Yingyan Yu
Frontiers of Medicine 2018, Volume 12, Issue 2, Pages 229-235 doi: 10.1007/s11684-017-0581-0
Keywords: molecular classification precision medicine pembrolizumab PD-1/PD-L1 MSI-H
The expression mode of hsa-miR-197 in uterine leiomyomas tissue and related bioinformatics analysis
Xu Qing,Fu Ziyi,Wu Xiaoli,Huangfu Yushuang and Ling Jing
Strategic Study of CAE 2014, Volume 16, Issue 5, Pages 99-104
Keywords: uterine leiomyomas hsa-miR-197 bioinformatics analysis target genes
Mengli Wang, Ruying Li, Qing Zhao
Frontiers of Environmental Science & Engineering 2019, Volume 13, Issue 3, doi: 10.1007/s11783-019-1127-2
Sludge digestion is critical to control the spread of ARGs from wastewater to soil. Fate of ARGs in three pretreatment-AD processes was investigated. UP was more efficient for ARGs removal than AP and THP in pretreatment-AD process. The total ARGs concentration showed significant correlation with 16S rRNA gene. The bacteria carrying ARGs could be mainly affiliated with Proteobacteria.
Keywords: Tetracycline resistance genes Sulfonamide resistance genes 16S rRNA gene Sludge pretreatment Anaerobic
Xinghua Gao, Hongduo Chen
Frontiers of Medicine 2014, Volume 8, Issue 1, Pages 1-5 doi: 10.1007/s11684-014-0309-3
Keywords: hyperthermia HPV immune response virus tumor
Frontiers of Environmental Science & Engineering 2021, Volume 15, Issue 6, doi: 10.1007/s11783-021-1415-5
• ARGs were detected in livestock manure, sludge, food waste and fermentation dregs.
Keywords: Antibiotic resistance genes Organic solid waste Aerobic composting Livestock manure Sludge
Title Author Date Type Operation
Advances on immune-related adverse events associated with immune checkpoint inhibitors
Yong Fan, Yan Geng, Lin Shen, Zhuoli Zhang
Journal Article
Expression profiles of genes and enzymes related to ascorbic acid metabolism in fruits of
Yingying CHEN,Zhihui ZHAO,Jin ZHAO,Mengjun LIU
Journal Article
Changes in lncRNAs and related genes in β-thalassemia minor and β-thalassemia major
Jing Ma,Fei Liu,Xin Du,Duan Ma,Likuan Xiong
Journal Article
Superenhancers activate the autophagy-related genes Beclin1 and LC3B to drive metastasis and drug resistance
Journal Article
Metagenomic analysis on resistance genes in water and microplastics from a mariculture system
Journal Article
Persistence of humoral and cellular immune response after SARS-CoV-2 infection: opportunities and challenges
Tangchun Wu
Journal Article
Molecular classification and precision therapy of cancer: immune checkpoint inhibitors
Yingyan Yu
Journal Article
The expression mode of hsa-miR-197 in uterine leiomyomas tissue and related bioinformatics analysis
Xu Qing,Fu Ziyi,Wu Xiaoli,Huangfu Yushuang and Ling Jing
Journal Article
Distribution and removal of antibiotic resistance genes during anaerobic sludge digestion with alkaline
Mengli Wang, Ruying Li, Qing Zhao
Journal Article
Hyperthermia on skin immune system and its application in the treatment of human papillomavirus-infected
Xinghua Gao, Hongduo Chen
Journal Article